Bruce Cronstein, MD
Recipient of the Arthritis Foundation's Lee C. Howley Sr. Prize
for Arthritis Scientific Research
Dr. Cronstein received his BA in History from Lake Forest College and his MD from the University of Cincinnati. After training in Internal Medicine at the University of Cincinnati and Lenox Hill Hospital in New York City, Dr. Cronstein completed a fellowship in Rheumatology at NYU School of Medicine where he was subsequently introduced to laboratory investigation in the laboratories of Drs. Rochelle Hirschhorn and Gerald Weissmann where he became totally immersed in experimental work. Dr. Cronstein’s first discovery in the laboratory was that adenosine, a molecule that is generated as a result of the utilization of ATP, the cell’s energy storage molecule, inhibits inflammation. From this initial seminal observation Dr. Cronstein went on to discover that the anti-inflammatory effects of methotrexate, the anchor drug for the treatment of Rheumatoid Arthritis, were mediated by an increase in adenosine release from cells at inflamed sites. While exploring the mechanisms for methotrexate’s toxic effects Dr. Cronstein discovered that adenosine is also involved in the pathologic mechanism leading to fatty liver and liver fibrosis. His laboratory is also exploring the effects of adenosine on bone metabolism. In subsequent studies Dr. Cronstein and his laboratory have demonstrated that adenosine plays an important part in wound healing and in the subsequent fibrosis and scarring that occurs in extensive wounds. Dr. Cronstein and his colleagues have also made important observations on the anti-inflammatory mechanism of action of such drugs as corticosteroids, colchicine and sulfasalazine and have helped to dissect the pathologic reactions involved in vascular inflammation, a common complication of rheumatic diseases. Dr. Cronstein is the 2013 recipient of the Lee C. Howley Sr. Prize for Research in Arthritis from the Arthritis Foundation and is a member of the Board of Directors of the American College of Rheumatology. Dr. Cronstein holds leadership positions at the NYU School of Medicine including as the founding co-Director of the NYU-HHC Clinical and Translational Science Institute and as the Director of the Division of Translational Medicine of the Department of Medicine.